Xiamen Sheng Lang SaiChuang Biological Technology Co., Ltd

CAS NO:9005-65-6  Tween 80

IUPAC name:Polyoxyethylene (20) sorbitan monooleate

Other names:Alkest TW 80,Tween 80

CAS Registry Number:9005-65-6 

Chemical formula:C64H124O26

Molar mass:1310 g/mol

Appearance:Amber colored viscous liquid

Density:1.06–1.09 g/mL, oily liquid

Boiling point: > 100°C

Solubility in water:Very soluble

Solubility in other solvents:soluble in ethanol, cottonseed oil, corn oil, ethyl acetate, methanol, toluene

Viscosity:300–500 centistokes (@25°C)

Uses

Food use

Polysorbate 80 is used as an emulsifier in foods.

For example in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting. Adding this substance prevents milk proteins from completely coating the fat droplets. This allows them to join together in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.

Health and beauty use

Polysorbate 80 is also used as a surfactant in soaps and cosmetics, or a solubilizer such as in a mouthwash. The cosmetic grade of polysorbate 80 may have more impurities than the food grade.

Medical use

Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the manufacture of the popular antiarrhythmic amiodarone. It is also used as an excipient in some European and Canadian influenza vaccines.Influenza vaccines contain 25 μg of polysorbate 80 per dose. It is also used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth. It is also used as an emulsifier in the estrogen-regulating drug Estrasorb.

Consumption and potential effects

In Europe and America, people eat about 100 mg of polysorbate 80 in foods per day on average. Polysorbate 80 is not carcinogenic. Rats fed with diets containing up to 5% polysorbate 80 by volume for 12 weeks showed no toxic effects. A 1997 study on two rats looked at the effect of consuming three doses by body weight of 0.5%/day on the sex organs of female rats and saw no abnormal changes in uterine weight. In general, polysorbate 80 is safe and well tolerated, notwithstanding the items listed below.

Crohn's disease

A small number of people may be sensitive to polysorbate 80, and it may be harmful to people with Crohn's disease.

Lowered body weight of offspring

A 2008 animal study concluded no observable adverse effects were seen at doses per body weight up to 1.85 ml/kg·day, which is equivalent to a 70 kg person consuming about 140 g of this substance per day for 21 days. However, administration of 16.783 ml/kg·day to pregnant rats lowered body weight in male and female offspring. This is equivalent to a person consuming about 1.3 kg of polysorbate 80 per day for 21 days.

Decreased fertility

A 1956 study saw no effect on reproduction in rats during their lifetime at up to 5% of their diet being polysorbate 80. Reproduction decreased at 20% of their diet. A 1993 study raised concerns that polysorbate 80 might decrease fertility in rats.

Impact on mouse gut microbiota

Relatively low concentrations of two commonly used emulsifiers, namely carboxymethylcellulose and polysorbate-80, induced low-grade inflammation and obesity/metabolic syndrome in wild-type hosts and promoted robust colitis in mice predisposed to this disorder. Use of germ-free mice and fecal transplants indicated that such changes in microbiota were necessary and sufficient for both low-grade inflammation and metabolic syndrome.

Laboratory use

Some mycobacteria contain a type of lipase (enzyme that breaks up lipid molecules). When added to a mixture of polysorbate 80 and phenol red, they cause the solution to change colour, so this is used as a test to identify the phenotype of a strain or isolate.

Our advantages:

Our advantages:

A. Saichuang Technology Co., ltd is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.

B. Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.

C. Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany, Russia, Australia, New Zealand.

D. Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.

E. High quality, good price, fast and safety delivery. Shipment by DHL, TNT, FEDEX, HKEMS, UPS, etc.



FAQ
Order Guide
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept bank transfer, Western Union or  Money gram or Bitcoin.

Q6:How long does it take to the goods arrived ?
A:It is Depending on your location, For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost should undertake by your side.

We specialized in manufacturing high quality and reliable raw material 
which are widely used in the fields of food, health, cosmetics, pharmaceuticals, and Bodybuilding
 
we have formed a technology and management team that cooperate closely with some  overseas Labs  all speak highly of our safe shipping and goods .
please do not hesitate to contact us.

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